Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,9-Dideoxyforskolin | dose dependent inhibition | Drosophila melanogaster | |
1,9-Dideoxyforskolin | dose dependent inhibition | Manduca sexta | |
7-O-Hemisuccinyl-7-deacetyl-forskolin | - |
Drosophila melanogaster | |
7-O-Hemisuccinyl-7-deacetyl-forskolin | - |
Manduca sexta | |
forskolin | 7beta-acetoxy-8,13-epoxy-1alpha,6beta,9alpha-dihydroxylabd-14-en-11-one, adenylate cyclase activator | Drosophila melanogaster | |
forskolin | 7beta-acetoxy-8,13-epoxy-1alpha,6beta,9alpha-dihydroxylabd-14-en-11-one, adenylate cyclase activator | Manduca sexta |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ecdysone + NADPH + O2 | Drosophila melanogaster | serves as precursor of ecdysterone, the active moulting hormone in larval insects | 20-hydroxyecdysone + NADP+ + H2O | - |
? | |
ecdysone + NADPH + O2 | Manduca sexta | serves as precursor of ecdysterone, the active moulting hormone in larval insects | 20-hydroxyecdysone + NADP+ + H2O | - |
? | |
ecdysone + NADPH + O2 | Drosophila melanogaster Canton S | serves as precursor of ecdysterone, the active moulting hormone in larval insects | 20-hydroxyecdysone + NADP+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
canton S strain | - |
Drosophila melanogaster Canton S | - |
canton S strain | - |
Manduca sexta | - |
tobacco hornworm | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ecdysone + reduced acceptor + O2 = 20-hydroxyecdysone + acceptor + H2O | NADPH-dependent monooxygenase containing cytochrome P-450, a heme-thiolate protein | Drosophila melanogaster | |
ecdysone + reduced acceptor + O2 = 20-hydroxyecdysone + acceptor + H2O | NADPH-dependent monooxygenase containing cytochrome P-450, a heme-thiolate protein | Manduca sexta |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fat body | larval | Drosophila melanogaster | - |
fat body | larval | Manduca sexta | - |
midgut | - |
Manduca sexta | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00000433 | - |
- |
Drosophila melanogaster |
0.0000197 | - |
fat body | Manduca sexta |
0.0001721 | - |
midgut | Manduca sexta |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-ecdysone + NADPH + O2 | - |
Drosophila melanogaster | 20-hydroxyecdysone + NADP+ + H2O | - |
? | |
alpha-ecdysone + NADPH + O2 | - |
Manduca sexta | 20-hydroxyecdysone + NADP+ + H2O | - |
? | |
alpha-ecdysone + NADPH + O2 | - |
Drosophila melanogaster Canton S | 20-hydroxyecdysone + NADP+ + H2O | - |
? | |
ecdysone + NADPH + O2 | serves as precursor of ecdysterone, the active moulting hormone in larval insects | Drosophila melanogaster | 20-hydroxyecdysone + NADP+ + H2O | - |
? | |
ecdysone + NADPH + O2 | serves as precursor of ecdysterone, the active moulting hormone in larval insects | Manduca sexta | 20-hydroxyecdysone + NADP+ + H2O | - |
? | |
ecdysone + NADPH + O2 | serves as precursor of ecdysterone, the active moulting hormone in larval insects | Drosophila melanogaster Canton S | 20-hydroxyecdysone + NADP+ + H2O | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
- |
Drosophila melanogaster |
6.5 | - |
- |
Manduca sexta |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P450 | essential | Drosophila melanogaster | |
cytochrome P450 | essential | Manduca sexta | |
NADPH | - |
Drosophila melanogaster | |
NADPH | - |
Manduca sexta |